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Newborn female, dysmorphic facial features

Newborn female, dysmorphic facial features

CT noncontrast

CT noncontrast

CT coronal reconstructions

CT 3D reconstructions (anterior view)


Findings:

Diffuse thinning of cortical mantle with absence of septum. Fused thalami and orbits.

DDX:

For cortical thinning: Severe hydrocephalus, hydranencephaly, holoprosencephaly.


Diagnosis:

Alobar holoprosencephaly.

Discussion:

Absence of septum help distinguish holoprosencephaly from the other DDx.


Submitted by Paritosh Khanna, MD, UW Neuroradiology Fellow