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Newborn female, dysmorphic facial features
CT noncontrast
CT noncontrast
CT coronal reconstructions
CT 3D reconstructions (anterior view)
Findings:
Diffuse thinning of cortical mantle with absence of septum. Fused thalami and orbits.
DDX:
For cortical thinning: Severe hydrocephalus, hydranencephaly, holoprosencephaly.
Diagnosis:
Alobar holoprosencephaly.
Discussion:
Absence of septum help distinguish holoprosencephaly from the other DDx.
Submitted by Paritosh Khanna, MD, UW Neuroradiology Fellow