Radiology Personnel

Stephen Dager, M.D.

Professor
Associate Director, Center on Human Development and Disability

Biography

Stephen R. Dager, M.D. is a Professor of Radiology and Adjunct Professor of Bioengineering at the University of Washington and Adjunct Professor of Psychiatry at the University of Utah.  He is a Research Affiliate and Associate Director of the University of Washington Center on Human Development and Disability.  He previously served as Interim Director of the University of Washington Autism Center.

At the national level, Dr. Dager chairs the Department of Defense Congressional-Mandated Medical Research Program’s Vision and Integration panels for autism research (Combating Autism Act), and is on the Scientific Advisory Board of Autism Speaks.  He is on the Editorial Boards of JAMA-Psychiatry and  Autism Research.

Dr. Dager obtained his undergraduate and medical degrees from the University of Nebraska and completed his residency training in Psychiatry at the University of Washington. He is a Diplomat of the American Board of Psychiatry and Neurology and a member of the American College of Neuropsychopharmacology. His primary research focus has been the development and application of novel imaging techniques to study brain mechanisms underlying neuropsychiatric disorders.

Dr. Dager directs NIH-funded research studying brain structural, metabolic and chemical abnormalities in neuropsychiatric disorders affecting both adults and young children.  As principal investigator of an ongoing “Neuroimaging of Autism” study funded by the NIH during the past 15 years, he is using structural MRI, DTI and a chemical imaging technique, proton echo-planar spectroscopic imaging (PEPSI), that was developed at the University of Washington Diagnostic Imaging Science Center (DISC), to longitudinally investigate brain development in children with autism or developmental delays in comparison to typically developing children between 3 and 15 years of age.  Dr. Dager additionally directs NIH ARRA-R01 research applying 3-D chemical imaging to study brain and white matter development in infants. Dr. Dager is UW PI of a collaborative longitudinal imaging study of infants at high-risk for autism that is being conducted between UNC Chapel Hill, Washington University, UPenn and the UW. He has directed NIH-funded imaging research investigating brain metabolic mechanisms underlying Panic Disorder and Bipolar Disorder, and the effects of treatment.  Dr. Dager and colleagues have developed techniques to non-invasively characterize brain pharmacokinetics of medications commonly used to treat depression and anxiety in children and adults. As a passionate consumer of caffeine in all forms, Dr. Dager also conducts research studying brain mechanisms involved in caffeine addiction.

Recent Publications

See all publications on Scopus

Language delay aggregates in toddler siblings of children with autism spectrum disorder
Marrus N., Hall L., Paterson S., Elison J., Wolff J., Swanson M., Parish-Morris J., Eggebrecht A., Pruett J., Hazlett H., Zwaigenbaum L., Dager S., Estes A., Schultz R., Botteron K., Piven J., Constantino J., Chappell C., Shaw D., McKinstry R., Evans A., Collins D., Pike G., Fonov V., Kostopoulos P., Das S., Gerig G., Styner M., Gu H.
Journal of Neurodevelopmental Disorders. 2018 Oct

Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: A potential gliogenetic mechanism underlying language-associated learning
Woo J., Kim J., Im J., Lee J., Jeong H., Park S., Jung S., An H., Yoon S., Lim S., Lee S., Ma J., Shin E., Han Y., Kim B., Lee E., Feng L., Chun H., Yoon B., Kang I., Dager S., Lyoo I., Lee C.
Molecular Psychiatry. 2018 Apr:1021-1030

Naturalistic Language Recordings Reveal “Hypervocal” Infants at High Familial Risk for Autism
Swanson M., Shen M., Wolff J., Boyd B., Clements M., Rehg J., Elison J., Paterson S., Parish-Morris J., Chappell J., Hazlett H., Emerson R., Botteron K., Pandey J., Schultz R., Dager S., Zwaigenbaum L., Estes A., Piven J., Shaw D., McKinstry R., Constantino J., Pruett J., Evans C., llins L., Pike B., Fonov V., Kostopoulos P., Das S., Gerig G., Styner M., Gu H.
Child Development. 2018 Mar:e60-e73

Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers
Marrus N., Eggebrecht A., Todorov A., Elison J., Wolff J., Cole L., Gao W., Pandey J., Shen M., Swanson M., Emerson R., Klohr C., Adams C., Estes A., Zwaigenbaum L., Botteron K., McKinstry R., Constantino J., Evans A., Hazlett H., Dager S., Paterson S., Schultz R., Styner M., Gerig G., Schlaggar B., Piven J., Pruett J.
Cerebral Cortex. 2018 Feb:750-763

Firefighters, posttraumatic stress disorder, and barriers to treatment: Results from a nationwide total population survey
Kim J., Dager S., Jeong H., Ma J., Park S., Choi Y., Lee S., Kang I., Ha E., Cho H., Kim E., Yoon S., Lyoo I.
PLoS ONE. 2018 Jan

A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism
Wolff J., Dimian A., Botteron K., Dager S., Elison J., Estes A., Hazlett H., Schultz R., Zwaigenbaum L., Piven J., Chappell C., Shaw D., McKinstry R., Constantino J., Pruett J., Pandey J., Paterson S., Evans A., Collins D., Pike G., Fonov V., Kostopoulos P., Das S., MacIntyre L., Gerig G., Styner M., Gu H.
Journal of Child Psychology and Psychiatry and Allied Disciplines. 2018 Jan

Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
Mitra A., Snyder A., Tagliazucchi E., Laufs H., Elison J., Emerson R., Shen M., Wolff J., Botteron K., Dager S., Estes A., Evans A., Gerig G., Hazlett H., Paterson S., Schultz R., Styner M., Zwaigenbaum L., Chappell C., Shaw D., McKinstry R., Constantino J., Pruett J., Collins D., Pike G., Fonov V., Kostopoulos P., Das S., Gu H., Schlaggar B., Piven J., Raichle M.
PLoS ONE. 2017 Nov

Subcortical Brain and Behavior Phenotypes Differentiate Infants With Autism Versus Language Delay
Swanson M., Shen M., Wolff J., Elison J., Emerson R., Styner M., Hazlett H., Truong K., Watson L., Paterson S., Marrus N., Botteron K., Pandey J., Schultz R., Dager S., Zwaigenbaum L., Estes A., Piven J., Chappell C., Shaw D., McKinstry R., Constantino J., Pruett J., Evans A., Collins D., Pike G., Fonov V., Kostopoulos P., Das S., Gerig G., Gu H.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2017 Nov:664-672

The Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder
Lewis J., Evans A., Pruett J., Botteron K., McKinstry R., Zwaigenbaum L., Estes A., Collins D., Kostopoulos P., Gerig G., Dager S., Paterson S., Schultz R., Styner M., Hazlett H., Piven J., Chappell C., Shaw D., Constantino J., Elison J., Pike G., Fonov V., Das S., Gu H.
Biological Psychiatry. 2017 Aug:176-185

Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder
Estes A., Munson J., John T., Dager S., Rodda A., Botteron K., Hazlett H., Schultz R., Zwaigenbaum L., Piven J., Guralnick M., Chappell J., Shaw D., McKinstry R., Constantino J., Pruett J., Paterson S., Evans A., Collins D., Pike G., Kostopolous P., Das S., Gerig G., Styner M., Gu H., Sullivan P., Wright F.
Journal of Autism and Developmental Disorders. 2017 Jun:1-11