Radiology Personnel

Lawrence MacDonald, Ph.D.

Research Associate Professor


Dr. Lawrence MacDonald received a B.S., in Physics from the University of Minnesota and a Ph.D. in Physics from the University of California, Los Angeles. He is currently a Research Assistant Professor in the Department of Radiology at the University of Washington. Dr. MacDonald’s research has focused on high-resolution dedicated nuclear imaging systems that included a pre-clinical SPECT-CT system and a small gamma camera for breast imaging and intra-operative sentinel lymph node imaging. His current work includes evaluation of clinical and physics performance of a positron emission mammography system and developing a fully tomographic high-resolution PET scanner that mounts to a conventional mammography gantry. This system will be optimized for PET-as-biomarker applications such as selection and monitoring breast cancer treatments, and clinical trials of new therapies.

Recent Publications

See all publications on Scopus

Simulation study of quantitative precision of the PET/X dedicated breast PET scanner
Zeng C., Kinahan P., Qian H., Harrison R., Champley K., MacDonald L.
Journal of Medical Imaging. 2017 Oct

Longitudinal monitoring of reconstructed activity concentration on a clinical time-of-flight PET/CT scanner
MacDonald L., Perkins A., Tung C.
Journal of Medical Imaging. 2017 Jan

Evaluation of event position reconstruction in monolithic crystals that are optically coupled
Morrocchi M., Hunter W., Del Guerra A., Lewellen T., Kinahan P., MacDonald L., Bisogni M., Miyaoka R.
Physics in Medicine and Biology. 2016 Nov:8298-8320

Positron emission mammography image interpretation for reduced image count levels
MacDonald L., Hippe D., Bender L., Cotter E., Voria P., Hallam P., Wang C., Haseley D., Kelly M., Parikh J., Beatty J., Rogers J.
Journal of Nuclear Medicine. 2016 Mar:348-354

Comparison of prone versus supine 18F-FDG-PET of locally advanced breast cancer: Phantom and preliminary clinical studies
Williams J., Rani S., Li X., Arlinghaus L., Lee T., MacDonald L., Partridge S., Kang H., Whisenant J., Abramson R., Linden H., Kinahan P., Yankeelov T.
Medical Physics. 2015 Jul:3801-3813

Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation
Mannelli L., MacDonald L., Mancini M., Ferguson M., Shuman W., Ragucci M., Monti S., Xu D., Yuan C., Mitsumori L.
European Radiology. 2015 May:1238-1246

Light-sharing interface for dMiCE detectors using sub-surface laser engraving
Hunter W., Miyaoka R., MacDonald L., McDougald W., Lewellen T.
IEEE Transactions on Nuclear Science. 2015 Feb:27-35

Multiplexing strategies for monolithic crystal PET detector modules
Pierce L., Hunter W., Haynor D., Macdonald L., Kinahan P., Miyaoka R.
Physics in Medicine and Biology. 2014 Sep:5347-5360

Effects of detector thickness on geometric sensitivity and event positioning errors in the rectangular PET/X scanner
Macdonald L., Hunter W., Kinahan P., Miyaoka R.
IEEE Transactions on Nuclear Science. 2013 Oct:3242-3252

SCOUT: A fast Monte-Carlo modeling tool of scintillation camera output
Hunter W., Barrett H., Muzi J., McDougald W., MacDonald L., Miyaoka R., Lewellen T.
Physics in Medicine and Biology. 2013 Jun:3581-3598