Radiology Personnel

David Marcinek, Ph.D.

Associate Professor

Biography

David Marcinek received his Ph.D. from Stanford University studying muscle metabolism in endothermic and ectothermic fish species. He came to the UW to work with Kevin Conley as a postdoctoral fellow where they developed NMR and optical spectroscopy tools to study the effects of age on skeletal muscle energetics. Since becoming faculty in the Department of Radiology he has been focused on the interaction between mitochondrial oxidative stress and energy metabolism in health and disease.

Education

1989-1993 B.A. – Biology, Kalamazoo College, Kalamazoo, MI

1993-2000 Ph.D. – Physiology, Stanford University, Stanford, CA

2000-2005 Postdoctoral Fellow, University of Washington, Seattle, WA

Recent Publications

See all publications on Scopus

Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon
Yeh A., Marcinek D., Meador J., Gallagher E.
Aquatic Toxicology. 2017 Sep:21-31

Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects
Crouch M., Knowels G., Stuppard R., Ericson N., Bielas J., Marcinek D., Syrjala K.
PLoS ONE. 2017 Jul

Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms
Moon Y., Balke J., Madorma D., Siegel M., Knowels G., Brouckaert P., Buys E., Marcinek D., Percival J.
Antioxidants and Redox Signaling. 2017 Jun:966-985

The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age
Sweetwyne M., Pippin J., Eng D., Hudkins K., Chiao Y., Campbell M., Marcinek D., Alpers C., Szeto H., Rabinovitch P., Shankland S.
Kidney International. 2017 May:1126-1145

Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice
Lefebvre K., Kendrick P., Ladiges W., Hiolski E., Ferriss B., Smith D., Marcinek D.
Harmful Algae. 2017 Apr:20-29

Skeletal muscle bioenergetics in aging and heart failure
Liu S., Marcinek D.
Heart Failure Reviews. 2017 Mar:167-178

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
Schweppe D., Chavez J., Lee C., Caudal A., Kruse S., Stuppard R., Marcinek D., Shadel G., Tian R., Bruce J.
Proceedings of the National Academy of Sciences of the United States of America. 2017 Feb:1732-1737

Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior
Ferriss B., Marcinek D., Ayres D., Borchert J., Lefebvre K.
Environment International. 2017 Jan:70-79

Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models
Dai D., Chiao Y., Martin G., Marcinek D., Basisty N., Quarles E., Rabinovitch P.
Progress in Molecular Biology and Translational Science. 2017 Jan:203-241

NAD+ repletion improves muscle function in muscular dystrophy and counters global parylation
Ryu D., Zhang H., Ropelle E., Sorrentino V., Mázala D., Mouchiroud L., Marshall P., Campbell M., Ali A., Knowels G., Bellemin S., Iyer S., Wang X., Gariani K., Sauve A., Cantó C., Conley K., Walter L., Lovering R., Chin E., Jasmin B., Marcinek D., Menzies K., Auwerx J.
Science Translational Medicine. 2016 Oct