University of Washington Radiochemistry Resources
The University of Washington Radiochemistry Resources (UWRR) is a specialized facility dedicated to the production of radiopharmaceuticals for human studies. The UWRR is run by the Department of Radiology is located in the University of Washington Health Sciences Building. The UWRR facility occupies seven laboratories with 2800 square feet of floor space. The laboratories are designed to facilitate all types of basic and translational imaging research. The facility is equipped with a Siemens RDS-111 cyclotron capable of producing 11 MeV protons for target irradiation. Potential isotopes generated include 18F, 11C, 13N and 15O (full list link?). The facility also includes the following:
This facility is currently licensed by the State of Washington for the manufacture of radiopharmaceuticals (license no. PHMF.FX.60522701). Benefits Expertise The UWRR is maintained at the highest standards by a full-time dedicated staff of four radio-chemists. Our team provides support and collaboration for specific research needs, including custom radiochemical syntheses, purification, and analytical method development, as well as IND/CMC generation. Clinical trial support encompasses production of established in-house radiostracers as well as development of novel biomarkers. Availability |
Contact Information Staff Lead: Steven Shoner, Ph.D. Radiopharmaceutical Production
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Compounds | Uses |
18F-Fluoroestradiol, 18FES | Breast Cancer Hormone Receptor Level Imaging |
3′-Deoxy-3′-[18F]fluorothymidine, 18FLT | Cell Proliferation Imaging |
18F-Fluoromisonidazol, 18FMISO | Imaging Hypoxia in Tumors and Other Tissues |
18F-DPA-714 | Neuroinflammation Imaging |
11C-PiB | Amyloid Imaging |
11C-mHED | Neurotransmitter Imaging |
11C-Verapamil | Transporter Imaging |
11C-flumazenil | GABA Receptor Imaging |
13N ammonia | Blood Flow Tracer |
11c Acetate | Fatty Acid Synthesis |