University of Washington Radiochemistry Resources

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Contact: Steven Shoner, Ph.D., scshoner@uw.edu

The University of Washington Radiochemistry Resources (UWRR) is a specialized facility dedicated to the production and development of radiopharmaceuticals for human studies.

The UWRR is run by the Department of Radiology is located in the University of Washington Health Sciences Building. The UWRR facility occupies seven laboratories with 2800 square feet of floor space. The laboratories are designed to facilitate all types of basic and translational imaging research.

The facility is equipped with a Siemens RDS-111 cyclotron capable of producing 11 MeV protons for target irradiation. Potential isotopes generated include ¹⁸F, ¹¹C, ¹³N and ¹⁵O

The facility also includes the following:

radiochemistry labs equipped with hot cells
four hot cells to facilitate production at high radiation levels
organic chemistry labs
GLP/GMP compliant pharmaceutical production clean room (120 ft²)
two synthesis boxes (GE TracerLab FX/FN and GE FastLab) for automated radiopharmaceutical synthesis and purification
Analytical chemistry laboratory
Analytical HPLCs with UV and radiation detection
gas chromatography with EI/ion trap mass detection
gamma counter for identification and quantitation of radioactive samples

This facility is currently licensed by the State of Washington for the manufacture of radiopharmaceuticals (license no. PHMF.FX.60522701).

Benefits

Expertise

The UWRR is maintained at the highest standards by a full-time dedicated staff of four radio-chemists. Our team provides support and collaboration for specific research needs, including custom radiochemical syntheses, purification, and analytical method development, as well as IND/CMC generation. Clinical trial support encompasses production of established in-house radiotracers as well as development of novel biomarkers.

Availability

Weekdays 8:00 am – 5:00 pm
Evenings and weekends upon request
Scheduling lead times approximate 1-4 weeks, dependent upon radiochemistry facility, cyclotron, and PET scanner availability

Please contact Steven Shoner, Ph.D., scshoner@uw.edu if you have any questions regarding the UW Radiochemistry Resources.

Submit a Radiochemistry Order

Compounds	Uses
¹⁸F-Fluoroestradiol, ¹⁸FES	Breast Cancer Hormone Receptor Level Imaging
3′-Deoxy-3′-[¹⁸F]fluorothymidine, ¹⁸FLT	Cell Proliferation Imaging
¹⁸F-Fluoromisonidazol, ¹⁸FMISO	Imaging Hypoxia in Tumors and Other Tissues
¹⁸F-DPA-714	Neuroinflammation Imaging
¹¹C-PiB	Amyloid Imaging
¹¹C-mHED	Neurotransmitter Imaging
¹¹C-Verapamil	Transporter Imaging
¹¹C-flumazenil	GABA Receptor Imaging
¹³N ammonia	Blood Flow Tracer
¹¹C Acetate	Fatty Acid Synthesis