UW Radiology

Radiochemistry Tracer Core

The University of Washington PET radiochemistry/radiopharmaceutical manufacturing facility is unique in the state of Washington as the only radiopharmaceutical manufacturing dedicated to the production of radiopharmaceuticals for program occupies seven laboratories with 2800 square feet of floor space and is located in the Molecular Imaging Center in the Department of Radiology at the University of Washington Medical Center. The laboratories have been designed to facilitate all types of basic and translational imaging research. These include a cyclotron vault, high level radiochemistry labs (hot labs) with hot cells, an organic chemistry lab, a radiochemistry lab, a pharmacy quality clean room (120 ft2), and an analytical chemistry facility.  The facility is equipped with a Siemens RDS-111 cyclotron.  This cyclotron produces 11 MeV protons that irradiate targets to produce a variety of isotopes, including 18F, 11C, 13N and 15O.   Available equipment includes four hot cells for high level radiation work, two synthesis boxes (GE TracerLab FX/FN and GE FastLab) for radiopharmaceutical production, several HPLCs with UV and radiation detectors, Gas Chromatography with mass detection, and a gamma counter for identification and quantitation of radioactive samples.

This facility is currently licensed by the State of Washington for the manufacture of radiopharmaceuticals (license no. PHMF.FX.60522701).

 

Contact Information

Staff Lead: Steven Shoner, Ph.D.
206 598-6711
scshoner@uw.edu

Please see below for list of the available compounds 

 

 

 

 

 

 

 

 

Compounds Uses
18F-Fluoroestradiol, 18FES Breast Cancer Hormone Receptor Level Imaging
3′-Deoxy-3′-[18F]fluorothymidine, 18FLT Cell Proliferation Imaging
18F-Fluoromisonidazol, 18FMISO Imaging Hypoxia in Tumors and Other Tissues
18F-DPA-714 Neuroinflammation Imaging
11C-PiB Amyloid Imaging
11C-mHED Neurotransmitter Imaging
11C-Verapamil  Transporter Imaging
11C-flumazenil GABA Receptor Imaging
13N ammonia Blood Flow Tracer
11c Acetate Fatty Acid Synthesis